Endocrine Abstracts

The major abnormality in type 1 diabetes is insulin deficiency. Type 2 diabetes is also characterized by an insulin secretory defect so that many patients are on insulin therapy. Methods of replacing insulin have improved throughout the decades, but there are still limiting factors that prevent the achievement of a better HbA1c levels such as hypoglycaemic events and glycaemic variability, weight gain and fatty liver. Additionally, most patients wish to do less insulin injecti...

Introduction: The most common sellar lesions are mainly due to pituitary adenomas, craniopharyngiomas and benign cysts. Rathke’s cleft cyst (RCC) is a developmental sellar or suprasellar cystic lesion, which rarely becomes symptomatic. Here, we present an interesting case of intra sellar RCC, with a presenting feature of acute pituitary apoplexy.Case report: A 39 year old healthy women was referred to the emergency room for sudden headache and fatig...

We herein describe a 55-year-old woman who showed a dramatic improvement in glucose control following treatment for co-existing acromegaly and Cushing’s syndrome. The co-occurrence of acromegaly and Cushing’s syndrome in one individual is extremely rare. This patient was diagnosed as having diabetes mellitus 7 years ago. Afterwards, in spite of insulin therapy, her hyperglycemia could not be well controlled. Endocrinological and radiological examinations revealed sub...

Introduction: Immunotherapy is an effective therapeutic choice increasingly prescribed in oncology. Endocrine toxicity is described among its side effects.Methods: A case of a patient treated with immunotherapy since January 2022 is hospitalized in the endocrinology department in Bichat Hospital.Results: Mr K, aged 46, treated with of anti-CTA4 and anti-PD1 inhibitors for melanoma. A month after the treatment the findings showed an...

Long-term benefit-risk ratio of IT remains poorly evaluated. The aim of this work was to determine the evolution of macroangiopathic complications 5 years after IT.21 out of the 36 prospectively followed islet-transplanted patients in a single center, had at least 5 years of follow-up and were included. Their initial features were: duration of C-peptide negative diabetes: 28±9years; age: 43±7years; BMI: 24±0.2 kg/m2; 8/21 kidney-transplant...

NC-CAH is diagnosed in pubertal/post-pubertal women because of androgen excess however, the risk of potential adrenal insufficiency is not known, and indication of systematic glucocorticoid replacement therapy is controversial.Design: Prospective controlled clinical study in a tertiary referral center. 20 women with NC-CAH (serum stimulated 17-OHP >10 ng/ml/250 μg, Synacthen) comparatively to matched healthy women, were included if they had not ...

Context: Craniopharyngiomas are often associated with an unfavorable prognosis but data on their long-term consequences are sparse.Objective: To identify markers of recurrence and factors associated with compromised social rehabilitation and altered quality of life (QoL) in a large cohort of patients with either childhood onset (CO) or adult onset (AO) craniopharyngioma.Methods: Retrospective analysis was performed for 171 patients...